Pharmacological- and Gene Therapy–Based Inhibition of Protein Kinase C / Enhances Cardiac Contractility and Attenuates Heart Failure
نویسندگان
چکیده
Jeffery N. Carr, Thomas F. Kimball, Timothy E. Hewett, Gerald W. Dorn II, Walter J. Koch and Michael Hambleton, Harvey Hahn, Sven T. Pleger, Matthew C. Kuhn, Raisa Klevitsky, Andrew Cardiac Contractility and Attenuates Heart Failure Enhances β / α Pharmacologicaland Gene Therapy-Based Inhibition of Protein Kinase C Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2006 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/CIRCULATIONAHA.105.59255
منابع مشابه
Short Communication Inhibition of PKC / With Ruboxistaurin Antagonizes Heart Failure in Pigs After Myocardial Infarction Injury
Rationale: Protein kinase C (PKC ) activity and protein level are induced during cardiac disease where it controls myocardial contractility and propensity to heart failure in mice and rats. For example, mice lacking the gene for PKC have enhanced cardiac contractility and reduced susceptibility to heart failure after long-term pressure overload or after myocardial infarction injury. Pharmacolog...
متن کاملIntegrative Physiology Inhibition of PKC / With Ruboxistaurin Antagonizes Heart Failure in Pigs After Myocardial Infarction Injury Short Communication
Rationale: Protein kinase C (PKC ) activity and protein level are induced during cardiac disease where it controls myocardial contractility and propensity to heart failure in mice and rats. For example, mice lacking the gene for PKC have enhanced cardiac contractility and reduced susceptibility to heart failure after long-term pressure overload or after myocardial infarction injury. Pharmacolog...
متن کاملInhibition of PKCα/β with ruboxistaurin antagonizes heart failure in pigs after myocardial infarction injury.
RATIONALE Protein kinase Cα (PKCα) activity and protein level are induced during cardiac disease where it controls myocardial contractility and propensity to heart failure in mice and rats. For example, mice lacking the gene for PKCα have enhanced cardiac contractility and reduced susceptibility to heart failure after long-term pressure overload or after myocardial infarction injury. Pharmacolo...
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BACKGROUND Apelin, the endogenous ligand for the G protein-coupled apelin receptor, is an important regulator of the cardiovascular homoeostasis. We previously demonstrated that apelin is one of the most potent endogenous stimulators of cardiac contractility; however, its underlying signaling mechanisms remain largely elusive. In this study we characterized the contribution of protein kinase C ...
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Protein kinase (PK)C , PKC , and PKC comprise the conventional PKC isoform subfamily, which is thought to regulate cardiac disease responsiveness. Indeed, mice lacking the gene for PKC show enhanced cardiac contractility and reduced susceptibility to heart failure. Recent data also suggest that inhibition of conventional PKC isoforms with Ro-32-0432 or Ro-31-8220 enhances heart function and ant...
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